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animation_offset="" logics=""]\n\nLe groupe de travail "Biologie Spatiale" du Cancéropôle GSO vous convie à son proc hain wébinaire "45 minutes Inside 3D reconstructions of the tumor micro environment in melanoma" le lundi 2 décembre à 11h30.\n\nCette 11èm e édition sera présentée par Ovidiu RADULESCU\, professeur de Biolog ie des Systèmes au Laboratoire sur les interactions hôte-pathogène (LPH I) à Montpellier.\n\nComme pour toutes les éditions de cette série\, la présentation aura un format court de type "Lab Reports"et sera suivie d' un temps d'échange.\n\nRésumé - 3D reconstructions of the tumor microe nvironment in melanoma\n\nIntratumoral metabolic heterogeneity is largely determined by the structure and organization of blood vessels\, which affe ct oxygen\, nutrient\, and drug gradients\, thereby influencing melanoma c ell plasticity and their response to therapies. Two-dimensional models can not accurately capture these gradients\, so we developed 3D digital tumor models that incorporate the spatial distribution of blood vessels from ser ial tumor sections. These 3D reconstructions form the basis of physical mo dels and can be used to predict oxygen and nutrient gradients\, as well as hypoxic regions in tumors\, where significant metabolic changes occur.\n\ nWe have also developed more complex models of the tumor microenvironment\ , accounting for tumor cell plasticity. These models predict zoning in res ponse to treatment\, with resistant and sensitive cells distributed accord ing to their proximity to drug and nutrient sources. Additionally\, they s uggest that a 'confine and kill' strategy—using immunotherapy followed b y targeted treatment—is more effective in delaying the development of re sistance compared to monotherapies or the reverse combination.\n\n[/fusion _text][fusion_button link="https://forms.office.com/pages/responsepage.asp x?id=2TQuxc6Dh0quYKgVoNNaVYDd8YoWZSRGrHHNOUfFg_hUQzU5S1FIUFBOTTRKNEZQUUdRN 00wS0hWTy4u" title="" target="_blank" link_attributes="" aria_role_button= "0" alignment_medium="" alignment_small="" alignment="center" modal="" hid e_on_mobile="small-visibility\,medium-visibility\,large-visibility" sticky _display="normal\,sticky" class="" id="" color="default" button_gradient_t op_color_hover="" hue="" saturation="" lightness="" alpha="" button_gradie nt_top_color="" button_gradient_bottom_color_hover="" button_gradient_bott om_color="" gradient_start_position="" gradient_end_position="" gradient_t ype="" radial_direction="" linear_angle="180" accent_hover_color="" accent _color="" type="" bevel_color="" bevel_color_hover="" border_top="" border _right="" border_bottom="" border_left="" border_radius_top_left="" border _radius_top_right="" border_radius_bottom_right="" border_radius_bottom_le ft="" border_hover_color="" border_color="" size="" padding_top="" padding _right="" padding_bottom="" padding_left="" fusion_font_family_button_font ="" fusion_font_variant_button_font="" font_size="" line_height="" letter_ spacing="" text_transform="" stretch="default" margin_top="" margin_right= "" margin_bottom="" margin_left="" icon="" icon_position="left" icon_divid er="no" hover_transition="none" animation_type="" animation_direction="lef t" animation_color="" animation_speed="0.3" animation_delay="0" animation_ offset=""]Inscription à la série de Webinaires 45 minutes Inside *[/fusi on_button][fusion_text columns="" column_min_width="" column_spacing="" ru le_style="" rule_size="" rule_color="" hue="" saturation="" lightness="" a lpha="" user_select="" content_alignment_medium="" content_alignment_small ="" content_alignment="center" hide_on_mobile="small-visibility\,medium-vi sibility\,large-visibility" sticky_display="normal\,sticky" class="" id="" margin_top="" margin_right="" margin_bottom="" margin_left="" fusion_font _family_text_font="" fusion_font_variant_text_font="" font_size="" line_he ight="" letter_spacing="" text_transform="" text_color="" animation_type=" " animation_direction="left" animation_color="" animation_speed="0.3" anim ation_delay="0" animation_offset="" logics=""]\n\n *Il n'est pas nécessa ire de vous réinscrire si vous avez déjà participé à un wébinaire\, le lien pour vous connecter est inchangé et vous sera rappelé\n\n[/fusio n_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_conta iner] ATTACH;FMTTYPE=image/jpeg:https://kgso.fr/wp-content/uploads/2024/11/GT_Bi ologie_Spatiale_.png CATEGORIES:0Webinaire,Biologie Spatiale,Evènement END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Paris X-LIC-LOCATION:Europe/Paris BEGIN:STANDARD DTSTART:20241027T020000 TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET END:STANDARD END:VTIMEZONE END:VCALENDAR